| Edinson Cavani - 311 Goals |
| Domestic goals are league goals scored in the top division of England, Spain, Italy or Germany |
| European goals are goals scored in the Champions League, excluding qualifying rounds |
| International goals are goals scored in the final rounds of the World Cup or Euros |
| Clubs | Total 302 | Domestic | European |
|---|---|---|---|
| Valencia | 5 | 5 | |
| 2022-2023 | 5 | 5 | |
| Manchester United | 12 | 12 | |
| 2021-2022 | 2 | 2 | |
| 2020-2021 | 10 | 10 | |
| Paris St Germain | 168 | 138 | 30 |
| 2019-2020 | 12 | 4 | 1 |
| 2018-2019 | 18 | 18 | 2 |
| 2017-2018 | 26 | 28 | 7 |
| 2016-2017 | 17 | 35 | 8 |
| 2015-2016 | 27 | 19 | 2 |
| 2014-2015 | 32 | 18 | 6 |
| 2013-2014 | 13 | 16 | 4 |
| Napoli | 83 | 78 | 5 |
| 2012-2013 | 29 | 29 | |
| 2011-2012 | 28 | 23 | 5 |
| 2010-2011 | 26 | 26 | |
| Palermo | 34 | 34 | |
| 2019-2020 | 13 | 13 | |
| 2018-2019 | 14 | 14 | |
| 2017-2018 | 5 | 5 | |
| 2016-2017 | 2 | 2 | |
| International | Total | World Cup | Copa A |
| Uruguay | 9 | 5 | 4 |
| 2021 | 2 | 2 | |
| 2019 | 2 | 2 | |
| 2018 | 3 | 3 | |
| 2014 | 1 | 1 | |
| 2010 | 1 | 1 |