| Champions League Top Scorers 1955-2025 -Lazio |
| 1 | Simone Inzaghi | 15 | 1999 | 2003 |
| 2 | Ciro Immobile | 9 | 2020 | 2023 |
| 3 | Claudio Lopez | 6 | 2000 | 2001 |
| 4 | Sinisa Mihajlovic | 5 | 1999 | 2000 |
| 5 | Goran Pandev | 4 | 2007 | 2007 |
| 6 | Pavel Nedved | 4 | 1999 | 2000 |
| 7 | Marcelo Salas | 4 | 1999 | 1999 |
| 8 | Joaquin Correa | 3 | 2020 | 2020 |
| 9 | DŽjan Stankovic | 3 | 1999 | 2001 |
| 10 | Juan Sebastian Veron | 3 | 1999 | 2000 |